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Published on: July 29, 2014
Opiate receptor avidity in the thalamus is sexually dimorphic in the elderly
R M Cohen1, R E Carson, T Sunderland
1Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland 20982-1274, USA. bob@shiloh.nimh.nih.gov
Abstract:
Opiate receptor avidity (B(')(max)/K(D)), was measured in the subcortex of nine females (five healthy subjects, four Alzheimer patients) and 15 males (seven healthy subjects, eight Alzheimer patients), 51-75 years of age, with the opiate receptor antagonist 6-deoxy-6-beta-[(18)F]fluoronaltrexone (cyclofoxy, CF) and a positron emission tomograph. CF avidity was 27.5% less in the thalamus of healthy women compared to healthy men and 48.5% less in Alzheimer disease female patients compared to male patients.
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