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Vanishing bile duct syndrome in Hodgkin's disease: case report
M S Rossini1, I Lorand-Metze, G B Oliveira
1Hematology and Blood Transfusion Center, State University of Campinas, Campinas, Brazil.
Context:
Liver damage is relatively common in patients affected by Hodgkin's disease. A smaller proportion of cases develops jaundice. Recently, the vanishing bile duct syndrome was described in Hodgkin's disease. The mechanisms of this severe complication have been poorly understood until now.
Objective:
To describe a rare case of intra-hepatic cholestasis due to vanishing bile duct syndrome.
Design:
Case report.
Case Report:
A 38-year-old male patient affected by Hodgkin's disease. Liver biopsy showed no detectable Hodgkin's disease. Intra-hepatic cholestasis was found and none of the six portal tracts analyzed contained normal bile ducts. The treatment was based on conventional and high-dose escalation chemotherapy. The patient died from an irreversible liver failure while in complete remission from Hodgkin's disease.