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[Diovan effectiveness in combined treatment of severe arterial hypertension]
Insights
Diovan effectively lowers blood pressure in severe hypertension when combined with other medications. This angiotensin-II antagonist demonstrated significant efficacy in 80% of patients, with minimal side effects.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Severe arterial hypertension requires effective treatment strategies.
- Angiotensin-II antagonists represent a novel class of antihypertensive agents.
Purpose of the Study:
- To evaluate the efficacy of Diovan (valsartan) as an add-on therapy for severe arterial hypertension.
- To assess the safety and hemodynamic effects of Diovan in combination therapy.
Main Methods:
- A study involving 15 patients with severe arterial hypertension.
- Diovan (80-160 mg/day) was administered for 8 weeks alongside existing antihypertensives (clofelin, beta-blockers, ACE inhibitors, diuretics).
- 24-hour ambulatory blood pressure monitoring, tolerance assessments, and hemodynamic evaluations were performed.
Main Results:
- Diovan achieved satisfactory blood pressure control in 80% of patients.
- 13.3% of patients showed no response to Diovan.
- A 6.7% withdrawal rate due to allergy was observed; only 2 patients experienced mild headaches.
Conclusions:
- Diovan is an effective component of combination therapy for severe arterial hypertension.
- The drug demonstrates a favorable safety profile when used with other antihypertensive classes.
Aim:
To assess effectiveness of diovan, a novel angiotensin-II antagonist, in combined hypotensive treatment of patients with severe arterial hypertension.
Material And Methods:
15 patients with severe arterial hypertension received diovan in a dose 80-160 mg/day for 8 weeks in combination with clofelin, beta-adrenoblockers, ACE inhibitors, diuretics prescribed before the start of diovan. Diovan effects were studied by 24-h monitoring of arterial pressure, tolerance, changes in blood counts, central hemodynamics.
Results:
Adjuvant hypotensive treatment with diovan lowered arterial pressure to satisfactory levels in 80% of patients. 13.3% did not respond to diovan. 6.7% of patients were withdrawn because of allergy. Only 2 patients of those who completed the diovan course developed side effects in first two weeks of the treatment--they had head ache.
Conclusion:
Diovan is effective in combination with clofelin, ACE inhibitors, diuretics, beta-adrenoblockers.