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Elevated nitric oxide metabolite levels in chronic sinusitis
R J Schlosser1, W D Spotnitz, E J Peters
1Department of Otolaryngology-Head and Neck Surgery, University of Virginia Health Sciences Center, USA.
Summary
Chronic sinusitis is linked to altered nitric oxide (NO) levels. This study found elevated NO metabolites in infected sinuses, which decreased during recovery, suggesting a role for NO in sinusitis pathogenesis.
Area of Science:
- Otorhinolaryngology
- Biochemistry
Background:
- Decreased exhaled nitric oxide (NO) is a known indicator in chronic sinusitis.
- The role of NO metabolites in the pathophysiology of chronic sinusitis requires further elucidation.
Purpose of the Study:
- To investigate the levels of NO metabolites in a rabbit model of chronic sinusitis.
- To correlate NO metabolite levels with disease severity and mucociliary function.
Main Methods:
- Measurement of nitrates, nitrites, and S-nitrosothiols in sinus lavages from infected, uninfected, and recovering rabbits.
- Assessment of mucociliary transport velocity.
- Histopathological and microbiological analysis of sinus tissues.
Main Results:
- Significantly elevated NO metabolite levels were observed in infected sinuses compared to uninfected controls (P<0.01).
- Mucociliary transport velocity was markedly reduced in infected sinuses (5.2 mm/minute) versus uninfected (16.0 mm/minute).
- NO metabolite levels decreased during the recovery phase, correlating with improved endoscopic appearance and histology.
Conclusions:
- Elevated NO metabolites are present during chronic sinusitis in this rabbit model.
- These elevated levels normalize during the recovery phase, indicating a dynamic role for NO.
- Further research is warranted to explore the connection between NO, epithelial autotoxicity, and host defense in chronic sinusitis.