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Related Experiment Videos

Elevated nitric oxide metabolite levels in chronic sinusitis.

R J Schlosser1, W D Spotnitz, E J Peters

  • 1Department of Otolaryngology-Head and Neck Surgery, University of Virginia Health Sciences Center, USA.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|October 6, 2000
PubMed
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Chronic sinusitis is linked to altered nitric oxide (NO) levels. This study found elevated NO metabolites in infected sinuses, which decreased during recovery, suggesting a role for NO in sinusitis pathogenesis.

Area of Science:

  • Otorhinolaryngology
  • Biochemistry

Background:

  • Decreased exhaled nitric oxide (NO) is a known indicator in chronic sinusitis.
  • The role of NO metabolites in the pathophysiology of chronic sinusitis requires further elucidation.

Purpose of the Study:

  • To investigate the levels of NO metabolites in a rabbit model of chronic sinusitis.
  • To correlate NO metabolite levels with disease severity and mucociliary function.

Main Methods:

  • Measurement of nitrates, nitrites, and S-nitrosothiols in sinus lavages from infected, uninfected, and recovering rabbits.
  • Assessment of mucociliary transport velocity.
  • Histopathological and microbiological analysis of sinus tissues.

Main Results:

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  • Significantly elevated NO metabolite levels were observed in infected sinuses compared to uninfected controls (P<0.01).
  • Mucociliary transport velocity was markedly reduced in infected sinuses (5.2 mm/minute) versus uninfected (16.0 mm/minute).
  • NO metabolite levels decreased during the recovery phase, correlating with improved endoscopic appearance and histology.

    • Conclusions:

    • Elevated NO metabolites are present during chronic sinusitis in this rabbit model.
    • These elevated levels normalize during the recovery phase, indicating a dynamic role for NO.
    • Further research is warranted to explore the connection between NO, epithelial autotoxicity, and host defense in chronic sinusitis.