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In vitro selected oligonucleotides as receptors in binding assays
1Department of Biological Science and Technology, Tokushima University, Minami-Josanjima, Tokushima, 770-8506, Japan.
Methods (San Diego, Calif.)
|October 6, 2000
Abstract:
This paper describes a new binding assay that uses oligodeoxyribonucleotides (DNAs) obtained by the in vitro selection method instead of antibodies. DNAs that specifically bound to a target molecule were selected, labeled with some probes, and then used to detect the target molecule by staining or competitive binding assay.