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Mizuo phenomenon observed by scanning laser ophthalmoscopy in a patient with Oguchi disease
1Department of Ophthalmology, Niigata University School of Medicine, Niigata, Japan. usuit@med.niigata-u.ac.jp
Purpose:
To elucidate the origin of the abnormal fundus reflex in Oguchi disease.
Methods:
The ocular fundus of a 63-year-old woman who showed a homozygous arrestin 1147delA mutation was observed by scanning laser ophthalmoscopy with the use of an argon blue laser (wavelength, 488 nm), a helium-neon laser (633 nm), and an infrared laser (780 nm).
Results:
Diffuse, fine, white particles, which do not exist in normal subjects, were clearly demonstrated only with the helium-neon laser. After 4-hour dark adaptation, the abnormal particles disappeared, but then they reappeared gradually during 30 minutes of light adaptation, in accordance with the golden metallic reflex.
Conclusion:
The white particles found by helium-neon laser could be the origin of the abnormal fundus reflex in Oguchi disease.