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[Saint John's Wort as an antidepressant].

P F Schulte1

  • 1Dagkliniek Ypestein, GGZ Noord-Holland Noord, NG Heiloo.

Nederlands Tijdschrift Voor Geneeskunde
|October 6, 2000
PubMed
Summary

St. John's wort (Hypericum perforatum) extract at 900 mg/day effectively treats mild to moderate depression. While generally safe with few side effects, potential drug interactions require careful consideration.

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Area of Science:

  • Pharmacology
  • Psychiatry
  • Herbal Medicine

Context:

  • St. John's wort (Hypericum perforatum) is increasingly requested by patients in the Netherlands, despite limited local awareness.
  • Previous research on hypericum extracts had moderate methodological quality.
  • Recent high-quality studies have emerged from European journals.

Purpose:

  • To evaluate the efficacy and safety of Hypericum perforatum extract for depression.
  • To assess the current state of research regarding its use in clinical practice.
  • To inform healthcare providers about its therapeutic potential and limitations.

Summary:

  • Hypericum perforatum extract, at a dosage of 900 mg/day, demonstrates efficacy in treating mild to moderately severe depressed outpatients.
  • The side effect profile is comparable to placebo.
  • Potential interactions with various medications, including protease inhibitors, warfarin, and oral contraceptives, have been reported.

Impact:

  • Hypericum extract can be considered for patients experiencing side effects from synthetic antidepressants.
  • Further research is needed to adequately study maintenance therapy with hypericum extract.
  • Clinicians should consider switching to synthetic antidepressants if hypericum treatment does not meet expectations.

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