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Immune function of small bowel and its related diseases
1University Department of Paediatric Gastroenterology, Royal Free Campus, London, U.K.
Abstract:
The small intestine is a major immunological organ with aggregated lymphoid tissue of Peyer's diffuse lymphoid tissue of lamina propria and intra-epithelial lymphocytes as 3 key components. Immunopathogenesis is of central importance for coeliac disease, Crohn's disease and gastrointestinal food allergy. Small intestinal enteropathy of variable severity, related to T-cell activation is common to all.