Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Molecular signaling and pulpal nerve development.

K Fried1, C Nosrat, C Lillesaar

  • 1Department of Neuroscience, Karolinska Institute, Stockholm, Sweden. Kaj.Fried@neuro.ki.se

Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists
|October 6, 2000
PubMed
Summary

Molecular factors guide nerve growth to developing teeth, with nerve growth factor and glial cell line-derived neurotrophic factor playing key roles. Tooth aging also impacts nerve structure and function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasticity of Dental Cell Types in Development, Regeneration, and Evolution.

Journal of dental research·2023
Same author

Chikungunya infection in pregnancy - reassuring maternal and perinatal outcomes: a retrospective observational study.

BJOG : an international journal of obstetrics and gynaecology·2020
Same author

Electronic Healthcare Records: an essential part of Health Telematics Applications.

Yearbook of medical informatics·2016
Same author

Use of intravenous tigecycline in patients with severe Clostridium difficile infection: a retrospective observational cohort study.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2016
Same author

Three-dimensional Imaging Reveals New Compartments and Structural Adaptations in Odontoblasts.

Journal of dental research·2015
Same author

The curse of a little of that human touch: is CGRP responsible?

Experimental neurology·2014

Area of Science:

  • Developmental Biology
  • Neuroscience
  • Dental Research

Background:

  • Tooth development involves complex epithelial-mesenchymal interactions.
  • Sensory pulpal innervation is established concurrently with tooth formation.
  • Axons are present in jaws before tooth development begins.

Purpose of the Study:

  • To review molecular factors influencing nerve growth into teeth.
  • To understand the molecular basis of pulpal axon remodeling during tooth replacement.
  • To explore age-related changes in dental innervation.

Main Methods:

  • Literature review of studies on tooth innervation and molecular signaling.
  • Analysis of growth factors and extracellular matrix molecules involved in nerve development.

Related Experiment Videos

  • Examination of age-related changes in dental nerves.

    • Main Results:

    • Nerve growth factor and glial cell line-derived neurotrophic factor are crucial for pulpal innervation.
    • Neurotrophin-3 and -4/5 appear not to be involved.
    • Extracellular matrix molecules likely influence growing pulpal axons.

    Conclusions:

    • Specific molecular signals regulate sensory nerve development and remodeling in teeth.
    • Age-related dental nerve changes warrant further investigation.
    • Understanding these factors is key to dental health and regeneration.