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Updated: Aug 11, 2026

Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells
10:27

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Regulation of STAT3 by direct binding to the Rac1 GTPase

A R Simon1, H G Vikis, S Stewart

  • 1Pulmonary and Critical Care Division, Tupper Research Institute, New England Medical Center, Boston, MA 02111, USA.

Science (New York, N.Y.)
|October 6, 2000
PubMed
Summary

The Rac1 guanosine triphosphatase regulates signal transducers and activators of transcription 3 (STAT3) activity. Activated Rac1 binds to STAT3, influencing its phosphorylation and nuclear translocation, suggesting a novel signaling pathway.

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