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Relationship between apparent diffusion coefficient and subsequent hemorrhagic transformation following acute
D C Tong1, A Adami, M E Moseley
1Stanford Stroke Center, Palo Alto, Calif, USA. dct@leland.Stanford.edu
Stroke
|October 7, 2000
Summary
Identifying patients at risk for secondary hemorrhagic transformation (HT) after ischemic stroke is crucial. Diffusion-weighted MRI, specifically apparent diffusion coefficient (ADC) values, can help predict HT development, aiding treatment decisions.
Area of Science:
- Neuroimaging
- Stroke Medicine
- Radiology
Background:
- Secondary hemorrhagic transformation (HT) is a complication after acute ischemic stroke.
- Identifying patients at high risk for HT is vital, especially for thrombolytic therapy.
- Diffusion-weighted magnetic resonance imaging (dMRI) may offer predictive capabilities.
Purpose of the Study:
- To investigate if diffusion-weighted MRI can identify patients at increased risk of secondary HT.
- To explore the relationship between apparent diffusion coefficient (ADC) values and subsequent HT development.
Main Methods:
- Retrospective analysis of 17 ischemic stroke patients with dMRI within 8 hours of onset.
- Calculation of apparent diffusion coefficient (ADC) histograms for ischemic areas.
- Comparison of ADC values in areas that developed HT versus those that did not.
Main Results:
- HT lesions showed a significantly higher percentage of low ADC values (
- All lesions that subsequently developed HT had >40% of pixels with low ADC values.
- Non-HT lesions had <31% of pixels with low ADC values.
Conclusions:
- Stroke regions destined for HT exhibit a significantly greater proportion of low ADC values.
- Early assessment of ADC values using dMRI may serve as a valuable tool for predicting secondary HT risk.