Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Phenobarbital plasma levels in neonates.

C E Pippenger, T S Rosen

    Clinics in Perinatology
    |March 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    This study highlights variability in neonatal phenobarbital use. A recommended dosage regimen involves a loading dose followed by maintenance, with plasma concentration monitoring for optimal seizure and withdrawal syndrome control.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Motion resistant pulse oximetry in neonates.

    Archives of disease in childhood. Fetal and neonatal edition·2003
    Same author

    Pharmacology of neural tube defects.

    Epilepsia·2003
    Same author

    Lemon-flavored cod liver oil and a multivitamin-mineral supplement for the secondary prevention of otitis media in young children: pilot research.

    The Annals of otology, rhinology, and laryngology·2002
    Same author

    Controversies in blood-level monitoring: reexamining its role in the treatment of epilepsy.

    Epilepsia·2000
    Same author

    An ecological approach to development in children with prenatal drug exposure.

    The American journal of orthopsychiatry·1999
    Same author

    Racial differences in free radical scavenging enzyme activity in children.

    Journal of child neurology·1999

    Area of Science:

    • Neonatal pharmacology
    • Clinical neurology

    Background:

    • Neonatal phenobarbital utilization shows significant variability.
    • Effective management of neonatal seizures and withdrawal syndromes requires precise dosing.

    Purpose of the Study:

    • To assess current neonatal phenobarbital utilization patterns.
    • To propose an optimized dosing strategy for phenobarbital in neonates.
    • To determine the therapeutic plasma concentration range for phenobarbital in neonates.

    Main Methods:

    • Pilot study design.
    • Analysis of neonatal phenobarbital administration records.
    • Pharmacokinetic monitoring of plasma phenobarbital concentrations.

    Main Results:

    Related Experiment Videos

  • Marked variation in phenobarbital dosing was observed.
  • A loading dose of 8-10 mg/kg for 2 days followed by 5-6 mg/kg maintenance is suggested.
  • Optimal plasma concentrations for seizure/withdrawal control range from 15-30 µg/mL.

    • Conclusions:

    • Standardized phenobarbital dosing protocols are needed for neonates.
    • Frequent plasma concentration monitoring is crucial for therapeutic efficacy and safety.
    • The proposed regimen aims to achieve therapeutic levels rapidly and maintain them effectively.