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Comparative study of thyroid function and types of thyroid dysfunction in two areas in Denmark with slightly
N Knudsen1, I Bülow, T Jørgensen
1Department of Internal Medicine I, Bispebjerg Hospital, DK 2400, Copenhagen, Denmark. danthyr.bbh@dadlnet.dk
European Journal of Endocrinology
|October 7, 2000
Summary
Thyroid dysfunction prevalence varied between Danish regions despite similar iodine excretion. Iodine deficiency may increase thyroid autonomy, particularly in older adults, impacting thyroid function.
Area of Science:
- Endocrinology
- Public Health
- Thyroid Research
Background:
- Thyroid dysfunction patterns are influenced by population iodine status.
- Iodine deficiency disorders (IDDs) require population-level evaluation parameters.
- Thyroid dysfunction prevalence may serve as an indicator for IDDs.
Purpose of the Study:
- To compare thyroid dysfunction prevalence in two Danish regions with differing iodine excretion levels.
- To investigate the relationship between iodine status and thyroid dysfunction patterns.
Main Methods:
- A comparative cross-sectional study involving 4649 participants aged 18-65 in Denmark.
- Iodine excretion levels were measured, and thyroid dysfunction assessed via blood samples, questionnaires, and ultrasonography.
Main Results:
- Median iodine excretion was lower in Aalborg (53 microg/l) than Copenhagen (68 microg/l).
- Higher prevalence of previously undiagnosed hyperthyroidism (>40 years) and hypothyroidism was observed in Aalborg.
- Serum TSH levels were lower in Aalborg and declined with age, unlike in Copenhagen.
Conclusions:
- Significant differences in thyroid dysfunction exist between regions with minor iodine excretion variations.
- Findings suggest increased thyroid autonomy in the more iodine-deficient region, especially among the elderly.
- Thyroid dysfunction patterns correlate with regional iodine status and thyroid structure.