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Related Experiment Videos

Anaphylaxis to calcitonin.

S L Porcel1, J A Cumplido, B de la Hoz

  • 1Department of Allergy, Ramón y Cajal Hospital, Madrid, Spain.

Allergologia Et Immunopathologia
|October 7, 2000
PubMed
Summary
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Salmon calcitonin can cause allergic reactions. This case study highlights anaphylaxis, suggesting an IgE-mediated hypersensitivity to salmon calcitonin, even with prior tolerance.

Area of Science:

  • Endocrinology
  • Immunology
  • Allergology

Background:

  • Calcitonin, a hormone from thyroid C cells, is used for osteomuscular diseases.
  • Allergic reactions to salmon calcitonin are rarely documented.
  • Previous episodes of rhinitis, conjunctivitis, and perspiration were noted after salmon calcitonin administration.

Observation:

  • A 60-year-old woman experienced immediate allergic symptoms post-salmon calcitonin administration.
  • Skin prick tests with salmon calcitonin were positive, while nasal challenges were negative.
  • Intramuscular challenge testing induced an immediate anaphylactic reaction.

Findings:

  • The patient exhibited a positive skin prick test to salmon calcitonin.
  • Intramuscular administration of salmon calcitonin triggered an anaphylactic reaction.

Related Experiment Videos

  • Leukocyte histamine release and serum tryptase levels did not show significant changes.

    • Implications:

    • This case suggests IgE-mediated hypersensitivity as a mechanism for salmon calcitonin-induced anaphylaxis.
    • Clinicians should consider calcitonin allergy in patients with unexplained allergic reactions.
    • Further research is needed to understand the prevalence and mechanisms of calcitonin allergy.