Related Experiment Videos
[Circadian rhythms of urinary parameters in children with glomerulonephritis]
Insights
Children with glomerulonephritis exhibit disrupted daily urinary rhythms, affecting excretion patterns and indicating internal and external biological discord. Healthy children show normal daily variations in urine parameters like creatinine and SOD activity.
Area of Science:
- Nephrology
- Chronobiology
- Pediatrics
Background:
- Circadian rhythms regulate physiological processes, including urinary excretion.
- Disruptions in biological rhythms are linked to various pathologies.
- Urinary parameter variations in children with kidney disease are not well-characterized.
Purpose of the Study:
- To investigate circadian rhythms of urinary parameters in healthy children.
- To compare these rhythms in children diagnosed with glomerulonephritis.
- To identify specific alterations in urinary circadian patterns associated with glomerulonephritis.
Main Methods:
- Collected 24-hour urine samples from healthy children and those with glomerulonephritis.
- Analyzed daily variations in urine volume, specific gravity, creatinine, MDA, and SOD activity.
- Compared circadian patterns and mean daily values between the two groups.
Main Results:
- Healthy children displayed significant daily variations in urinary parameters.
- Children with glomerulonephritis showed altered circadian rhythms and mean daily values.
- Observed inversions in group and individual urinary excretion patterns in the glomerulonephritis cohort.
Conclusions:
- Glomerulonephritis in children is associated with significant disruptions in urinary circadian rhythms.
- These disruptions suggest a discordance between internal and external biological rhythms.
- Urinary parameter monitoring may offer insights into the chronobiological impact of glomerulonephritis.
Abstract:
Circadian rhythms of urinary parameters were studied in healthy children and those with glomerulonephritis. In healthy children, urinary excretion of many substances rhythmically varied during a day. Variations were related to the volume and specific gravity of urine, to the levels of creatinine, MDA, and SOD activities. Children with glomerulonephritis showed changes in values of circadian rhythm of urine parameters. These disorders included changes in circadian variations and mean daily values, inversion of group and individual excretion patterns, which indicates that there is an external and internal disagreement of biological rhythms in children with glomerulonephritis.