Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional testing: renin studies.

C S Wilcox1

  • 1Division of Nephrology and Hypertension, Georgetown University Medical Center, Washington, DC 20007, USA.

Seminars in Nephrology
|October 7, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endothelial prostaglandin D<sub>2</sub> opposes angiotensin II contractions in mouse isolated perfused intracerebral microarterioles.

Journal of the renin-angiotensin-aldosterone system : JRAAS·2020
Same author

High-salt diet induces outward remodelling of efferent arterioles in mice with reduced renal mass.

Acta physiologica (Oxford, England)·2016
Same author

Increased hydrogen peroxide impairs angiotensin II contractions of afferent arterioles in mice after renal ischaemia-reperfusion injury.

Acta physiologica (Oxford, England)·2016
Same author

Repeated mixing and isolation: measuring chronic, intermittent stress in Holstein calves.

Journal of dairy science·2013
Same author

Feeding behaviors of transition dairy cows fed glycerol as a replacement for corn.

Journal of dairy science·2012
Same author

Molecular recognition in aqueous media. Conformationally restricted water-soluble cyclophanes derived from 6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine.

Journal of the American Chemical Society·2011

Angiotensin converting enzyme inhibitors (ACEIs) significantly improve the accuracy of tests for renovascular hypertension. The captopril-stimulated plasma renin activity (PRA) test shows over 90% sensitivity in detecting this condition.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Diagnostic Imaging

Background:

  • Static tests for plasma renin activity (PRA) and renal vein renins lack sensitivity for diagnosing renovascular hypertension.
  • Renin-sodium profiling is insufficient for reliable screening of renovascular hypertension.

Purpose of the Study:

  • To evaluate the diagnostic accuracy of angiotensin converting enzyme inhibitors (ACEIs) in screening for renovascular hypertension.
  • To assess the sensitivity of ACEI-stimulated PRA and renogram tests in detecting functional renovascular hypertension.

Main Methods:

  • Utilized captopril-stimulated plasma renin activity (PRA) testing.
  • Assessed ACEI-induced changes in renogram parameters.
  • Validated tests against functional outcomes post-intervention for renal artery stenosis.

Related Experiment Videos

Main Results:

  • Captopril-stimulated PRA tests demonstrate high sensitivity (>90%) for renovascular hypertension when validated functionally.
  • ACEI-stimulated PRA and renogram tests reflect a shared pathophysiology: reduced post-stenotic kidney vascular resistance and decreased GFR.
  • Both ACEI-PRA and ACEI-renogram tests exhibit >90% sensitivity for detecting functional renovascular hypertension under protocol conditions.

Conclusions:

  • ACEI-stimulated tests offer a sensitive method for detecting functional renovascular hypertension.
  • The observed variations in test accuracy may stem from using functional tests for anatomical screening.
  • A selective reduction in postglomerular vascular resistance is a key abnormality in ACEI-sensitive renovascular hypertension.