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The FMRFamide-like neuropeptide AF2 is present in the parasitic nematode Haemonchus contortus
C D Keating1, L Holden-Dye, M C Thorndyke
1Department of Physiology and Pharmacology, University of Southampton, Bassett Crescent East.
Parasitology
|November 1, 1995
Abstract:
Peptides belonging to the FMRFamide family are widely distributed amongst invertebrates. We report here on the isolation of the FMRFamide neuropeptide AF2 (Lys-His-Glu-Tyr-Leu-Arg-Phe-NH2) from the parasitic nematode Haemonchus contortus. Immunocytochemical techniques showed that FMRFamide-like material was distributed in several regions of these organisms including nerve cords and cell bodies of the central nervous system. AF2 was isolated using a method that employed 6 steps of reverse-phase HPLC. The concentration of AF2 in this organism was approximately 30 pmol/g of nematode.