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Cyclophosphamide-induced immunological tolerance: recovery leads to a memory state
Folia Biologica
|January 1, 1975
Tolerance to SRBC has been induced in adult mice by the aid of cyclophosphamide, and the duration of the tolerant state has been tested by a second injection of antigen at different times thereafter. As evidenced by 19S and 7S PFC 4 days after challenge, tolerance in this model is of relatively short duration and leads spontaneously to a memory state.
Tolerance to SRBC has been induced in adult mice by the aid of cyclophosphamide, and the duration of the tolerant state has been tested by a second injection of antigen at different times thereafter. As evidenced by 19S and 7S PFC 4 days after challenge, tolerance in this model is of relatively short duration and leads spontaneously to a memory state.