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Tissue distribution and variant characterization of human herpesvirus (HHV)-6: increased prevalence of HHV-6A in

N Akhyani1, R Berti, M B Brennan

  • 1Viral Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.

The Journal of Infectious Diseases
|October 7, 2000
PubMed

Insights

Human herpesvirus 6 (HHV-6) DNA was detected in serum and urine of multiple sclerosis (MS) patients. The neurotropic HHV-6A variant found supports its role in MS pathogenesis.

Area of Science:

  • Neurovirology
  • Immunology
  • Human Herpesviruses

Background:

  • Human herpesvirus 6 (HHV-6) is implicated in multiple sclerosis (MS) pathogenesis.
  • Previous studies utilized serologic, molecular, and histopathologic data.

Purpose of the Study:

  • To determine HHV-6 distribution in MS patient body fluids.
  • To investigate the presence of HHV-6 in serum, saliva, urine, and lymphocytes.

Main Methods:

  • Molecular detection of HHV-6 DNA.
  • Analysis of various bodily fluids from MS patients.

Main Results:

  • HHV-6 DNA was found in serum and uniquely in urine of MS patients.
  • The detected HHV-6 was predominantly the neurotropic HHV-6A variant.
  • Viral sequences were identified in cell-free compartments.

Conclusions:

  • HHV-6 DNA detection in MS patient fluids supports its potential role in disease.
  • The findings suggest HHV-6A may contribute to the pathogenesis of multiple sclerosis.

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