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Maintenance therapy in Crohn's disease.

H Steinhart1

  • 1Mount Sinai Hospital, University of Toronto, Toronto, Canada. hsteinhart@mtsinai.on.ca

Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie
|October 7, 2000
PubMed
Summary

For active Crohn's disease, various drugs offer symptom relief. However, for long-term remission, immunosuppressive agents and anti-TNF therapies show promise, while others have limited benefits or risks.

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Area of Science:

  • Gastroenterology
  • Immunology
  • Pharmacology

Background:

  • Crohn's disease management involves diverse drug classes for active symptoms.
  • Recurrent Crohn's disease significantly impacts patient quality of life.
  • Existing therapies and emerging biologics aim to control the condition.

Purpose of the Study:

  • To review the efficacy of various drug therapies for Crohn's disease maintenance.
  • To assess the long-term benefits and risks of different treatment options.

Main Methods:

  • Review of existing evidence on drug therapies for Crohn's disease maintenance.
  • Analysis of therapeutic gain, toxicity, and steroid-sparing potential.

Main Results:

  • Most drugs effective for active disease show limited benefit in maintenance therapy.
  • Systemic glucocorticoids, budesonide, mesalazine, sulphasalazine, and antibiotics offer marginal gain or long-term toxicity.
  • Immunosuppressive agents (azathioprine, 6-mercaptopurine, methotrexate) and anti-TNF antibodies demonstrate efficacy in maintaining remission.

Conclusions:

  • Immunosuppressive agents and anti-TNF therapies are beneficial for Crohn's disease maintenance.
  • Further research is needed to determine the long-term safety, efficacy, and cost-effectiveness of maintenance therapies.

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