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Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation
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Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation

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Effects of modifying topoisomerase II levels on cellular recovery from radiation damage

D K Gaffney1, M Lundquist, R L Warters

  • 1Department of Radiation Oncology, University of Utah Medical Center, Salt Lake City, Utah 84132, USA.

Radiation Research
|October 7, 2000
PubMed

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DNA Topoisomerases

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Nucleotide Excision Repair

DNA Distortion and Damage
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DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
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Inhibitors of Bacterial DNA Synthesis

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