Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Relationships between enterococcal virulence and antimicrobial resistance.

L M Mundy¹, D F Sahm, M Gilmore

¹Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA. lmundy@imgate.wustl.edu

Clinical Microbiology Reviews

|October 12, 2000

Summary

Enterococci infections are difficult to treat due to antibiotic resistance and the bacteria's intrinsic virulence. Understanding these factors is key to managing enterococcal disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Multi-camera imaging to characterize jet and liner uniformity on the Plasma Liner Experiment (PLX).

The Review of scientific instruments·2023

Same author

ArI/ArII laser induced fluorescence system for measurement of neutral and ion dynamics in a large scale helicon plasma.

The Review of scientific instruments·2016

Same author

Antimicrobial resistance and resistance mechanisms of Enterobacteriaceae in ICU and non-ICU wards in Europe and North America: SMART 2011-2013.

Journal of global antimicrobial resistance·2016

Same author

In vitro activity of tedizolid against Staphylococcus aureus and Streptococcus pneumoniae collected in 2013 and 2014 from sites in Latin American countries, Australia, New Zealand, and China.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2016

Same author

Comparative in vitro activities of ceftaroline and ceftriaxone against bacterial pathogens associated with respiratory tract infections: results from the AWARE surveillance study.

The Journal of antimicrobial chemotherapy·2016

Same author

A pilot survey of an attempt to promote breast-feeding.

Irish journal of medical science·2016

Area of Science:

Clinical Medicine
Microbiology
Infectious Diseases

Background:

Enterococci pose significant clinical challenges, often infecting immunocompromised patients undergoing antibiotic treatment.
The management of enterococcal infections is complicated by the rise of antibiotic resistance within these bacteria.
Antibiotic therapy can disrupt normal flora, increasing colonization by resistant enterococci.

Purpose of the Study:

To review the virulence of enterococci, distinguishing it from antimicrobial resistance.
To identify current knowledge gaps regarding enterococcal virulence and disease causation.

Main Methods:

Literature review focusing on enterococcal virulence factors.
Analysis of the interplay between intrinsic virulence and antibiotic resistance.

Related Experiment Videos

Examination of factors influencing enterococcal colonization and infection establishment.

Main Results:

Enterococcal infections result from a combination of intrinsic virulence and antibiotic resistance.
Antibiotic use can promote the growth of resistant enterococci by altering gut microbiota.
The probability of infection is influenced by the bacterial burden and host factors.

Conclusions:

Both intrinsic virulence and acquired antibiotic resistance are critical contributors to enterococcal disease.
Further research is needed to fully elucidate the mechanisms of enterococcal virulence.
Understanding these distinct but complementary factors is essential for effective treatment strategies.