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Antiplasmodial activity of isoflavones from Andira inermis
C Kraft1, K Jenett-Siems, K Siems
1Institut für Pharmazie (Pharmazeutische Biologie), Freie Universität Berlin, Königin-Luise Str. 2-4, D-14195, Berlin, Germany.
Abstract:
The stem bark and seeds of Andira inermis, Fabaceae, are employed as a purgative, vermifuge, and febrifuge. In particular, the powdered bark is claimed to be efficacious in intermittent fever. Bioassay-guided fractionation of lipophilic extracts from the stems and leaves yielded six isoflavones: biochanin A, calycosin, formononetin, genistein, pratensein, and prunetin. Calycosin (3', 7-dihydroxy-4'-methoxyisoflavone) and genistein (4',5, 7-trihydroxyisoflavone) have been shown to possess in vitro activity against the chloroquine-sensitive strain poW and the chloroquine-resistant clone Dd2 of Plasmodium falciparum.