Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

(&mgr;-2, 6-Bis

Brito1, Bortoluzzi, Greatti

  • 1Departamento de Quimica - UFSC, 88040-900 Florianopolis, SC, Brazil. adajb@qmc.ufsc.br.

Acta Crystallographica. Section C, Crystal Structure Communications
|October 12, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Growth, metabolic rate, and digestive enzyme activity in the white shrimp Litopenaeus setiferus early postlarvae fed different diets.

Journal of experimental marine biology and ecology·2000
Same author

Tiling the plane without supersymmetry

Physical review letters·2000
Same author

Byte structure variable length coding (BS-VLC): a new specific algorithm applied in the compression of trajectories generated by molecular dynamics

Journal of chemical information and computer sciences·2000
Same author

Patient-Related and Angiographic Predictors of Restenosis After Excimer Laser Coronary Angioplasty.

The Journal of invasive cardiology·2000
Same author

Death and Transfiguration of a Triple Junction in the South Atlantic

Science (New York, N.Y.)·1997
Same author

[A proposal for worker's health surveillance with a gender perspective]

Cadernos de saude publica·1997

This study synthesized a binuclear nickel compound as a urease active site model. The nickel complex features a bridging phenoxo group and water ligands, mimicking the enzyme's structure.

Area of Science:

  • Inorganic Chemistry
  • Bioinorganic Chemistry
  • Coordination Chemistry

Background:

  • Urease is a crucial enzyme in the urea cycle.
  • Understanding urease active sites aids in designing inhibitors and catalysts.
  • Nickel ions are central to the active site of many urease enzymes.

Purpose of the Study:

  • To synthesize a binuclear nickel compound that models the active site of urease.
  • To investigate the structural and coordination properties of the synthesized nickel complex.

Main Methods:

  • Synthesis of the binuclear nickel compound [Ni(2)(C(33)H(29)N(4)O(3))(H(2)O)(4)]C(2)H(3)O(2).C(3)H(7)NO.0.75H(2)O.
  • Characterization of the ligand 2,6-bis[(2-hydroxyphenyl)(2-pyridylmethyl)amino]methyl-4-methylphenol ate (BPPMP(3-)).
  • Crystallographic analysis to determine the coordination geometry and bridging interactions.

Related Experiment Videos

Main Results:

  • The synthesized compound features a binuclear nickel cation with a bridging phenoxo oxygen atom.
  • The ligand BPPMP(3-) coordinates in a meridional fashion around the two Ni(II) ions.
  • Each Ni(II) ion achieves an octahedral coordination environment with four water molecules.

Conclusions:

  • The binuclear nickel complex serves as a functional model for the urease active site.
  • The structural arrangement highlights the importance of bridging ligands in dinuclear metal centers.
  • This model provides insights into the coordination chemistry relevant to metalloenzymes.