Correlation of serum creatinine concentration and amikacin half-life

The half-life of amikacin in serum has been measured following the administration of a single intravenous injection of 7 mg/kg in nine adult patients with varying degrees of renal function impairment and in four patients with normal renal function. A linear relationship between the half-life and the serum concentration has been found, suggesting that half-life of amikacin in serum can be calculated by multiplying the serum creatinine (in mg/100 ml) by 3.