Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rickets then and now.

H E Harrrison, H C Harrison

    The Journal of Pediatrics
    |December 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Nutritional rickets is rare due to fortified foods. However, skeletal disorders persist, stemming from vitamin D metabolism issues or kidney problems affecting phosphate levels.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The regeneration of liver protein in the rat.

    The Journal of biological chemistry·2010
    Same author

    Potassium deficiency in patients with steatorrhea.

    American journal of diseases of children (1911)·2010
    Same author

    Potassium deficiency in a case of lymphosarcoma with the sprue syndrome.

    The American journal of medicine·2010
    Same author

    BIOCHEMICAL STUDIES ON SHOCK : III. THE ROLE OF THE LIVER AND THE HEPATIC CIRCULATION IN THE METABOLIC CHANGES DURING HEMORRHAGIC SHOCK IN THE RAT AND THE CAT.

    The Journal of experimental medicine·2009
    Same author

    Breast reconstruction after failed conservation.

    Annals of the Royal College of Surgeons of England·2009
    Same author

    An approach to the management of paroxysmal laryngospasm.

    The Journal of laryngology and otology·2008
    Same journal

    Respiratory Syncytial Virus Immunization Disparities in Mothers and Infants at the Birth Hospitalization: A Cross-Sectional Study.

    The Journal of pediatrics·2026
    Same journal

    Blood-Based Biomarkers Predict Cerebral Palsy and Cognitive Delay in Hypoxic-Ischemic Encephalopathy: A Secondary Analysis of the HEAL Randomized Controlled Trial.

    The Journal of pediatrics·2026
    Same journal

    Does Mild Head Injury in Childhood Affect Later School Performance? A Sibling Comparison Cohort Study.

    The Journal of pediatrics·2026
    Same journal

    Risk Factors for Mortality and Age at Discharge in Preterm Infants with Congenital Heart Disease.

    The Journal of pediatrics·2026
    Same journal

    To Cool or Not to Cool in Low- and Middle-Income Countries:? A Call for Resources, Training and Shared Knowledge.

    The Journal of pediatrics·2026
    Same journal

    Responsible Research Practices in Pediatrics: How Reporting Guidelines Can Be Used to Improve Trial Design and Conduct.

    The Journal of pediatrics·2026
    See all related articles

    Area of Science:

    • Endocrinology
    • Nutritional Science
    • Pediatric Orthopedics

    Background:

    • Nutritional vitamin D-deficiency rickets is now uncommon due to irradiated ergosterol fortification in food.
    • Skeletal disorders related to vitamin D function abnormalities continue to be a clinical concern.
    • These disorders present diagnostic challenges, requiring precise classification.

    Purpose of the Study:

    • To classify skeletal disorders related to vitamin D function abnormalities.
    • To differentiate between disorders of active vitamin D metabolite deficiency and renal tubular dysfunction.
    • To outline the theoretical basis for treating these distinct conditions.

    Main Methods:

    • Review and classification of skeletal disorders based on vitamin D metabolism and renal function.

    Related Experiment Videos

  • Analysis of the biochemical pathways involved in vitamin D activation and phosphate regulation.
  • Description of clinical entities within the two identified groups.

    • Main Results:

    • Skeletal disorders are categorized into two main groups: 1,25-dihydroxyvitamin D deficiency and renal hypophosphatemia due to renal tubular abnormalities.
    • The first group involves insufficient levels of the active vitamin D metabolite.
    • The second group presents with hypophosphatemia despite normal vitamin D metabolism, linked to kidney function.

    Conclusions:

    • Accurate classification of vitamin D-related skeletal disorders is crucial for effective management.
    • Understanding the specific defect—either in vitamin D activation or renal phosphate handling—guides therapeutic strategies.
    • Treatment approaches are tailored to address the underlying cause of the skeletal disorder.