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Nanomanipulation of Single RNA Molecules by Optical Tweezers
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The unfolding of our understanding of RNA structure: a personal reflection

U Z Littauer1

  • 1Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel. bnlitaur@weizmann.ac.il

Biophysical Chemistry
|October 12, 2000
PubMed

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RNA Structure01:23

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RNA Stability01:53

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
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RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
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