Cerebral vasculopathy and multiple infarctions in a woman with carcinomatous meningitis while on treatment with

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S Kastenbauer1, M Wiesmann, H W Pfister

  • 1Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians University, Munich, Germany.

Journal of Neuro-Oncology
|October 12, 2000
PubMed

We report on a 33-year-old woman with carcinomatous meningitis due to carcinoma of the breast who developed multiple cerebral infarctions within four days after intrathecal chemotherapy with methotrexate. MR angiography revealed a narrowing of basal cerebral arteries, which is consistent with vasculopathy. The vasculopathy was probably due to carcinomatous meningitis itself, an acute toxic effect of methotrexate, or a combination of both.

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