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A randomized trial of 13-Cis retinoic acid in children with advanced neuroblastoma after high-dose therapy

J A Kohler1, J Imeson, C Ellershaw

  • 1Child Health, Southampton General Hospital, Southampton, United Kingdom.

British Journal of Cancer
|October 12, 2000
PubMed

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...