Jove
Visualize
Contact Us

Related Experiment Videos

A model of pattern formation based on signaling pathways.

F W Cummings1

  • 1Department of Physics, University of California, Riverside, CA 92521, USA. fredwc@earthlink.net

Journal of Theoretical Biology
|October 12, 2000
PubMed
Summary

This study presents a model for early embryo pattern formation, focusing on the roles of Wnt kinase and RPTP phosphatase signaling pathways. This model complements short-range patterning mechanisms like Delta/Notch signaling.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The interaction of surface geometry with morphogens.

Journal of theoretical biology·2002
Same author

Spatial patterning via PTP adhesive phosphatases.

Journal of theoretical biology·1999
Same author

Waves of pattern formation and signal pathways.

Journal of theoretical biology·1999
Same author

A model of growth and form based on adhesion molecules.

Journal of theoretical biology·1996
Same author

A model of morphogenetic pattern formation.

Journal of theoretical biology·1990
Same author

On surface geometry coupled to morphogen.

Journal of theoretical biology·1989
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Developmental Biology
  • Cell Signaling
  • Mathematical Modeling

Background:

  • Early embryonic development relies on precise pattern formation.
  • Kinase and phosphatase interactions are crucial for cellular signaling.
  • Wnt and RPTP phosphatase pathways are key signaling families.

Purpose of the Study:

  • To present a computational model for early embryonic pattern formation.
  • To investigate the role of Wnt kinase and RPTP phosphatase signaling in this process.
  • To explore how this long-range signaling complements short-range mechanisms.

Main Methods:

  • Development of a mathematical model.
  • Analysis of kinase-phosphatase interactions.
  • Comparison with known short-range signaling pathways.

Related Experiment Videos

Main Results:

  • The model highlights the importance of Wnt and RPTP phosphatase pathways in long-range pattern formation.
  • It demonstrates how these pathways can coordinate developmental processes.
  • The model provides a framework for understanding signaling integration.

Conclusions:

  • Wnt and RPTP phosphatase signaling are essential for early embryonic patterning.
  • This long-range signaling mechanism works in concert with short-range pathways like Delta/Notch.
  • The presented model offers insights into the complexity of developmental signaling.