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Identification of a novel human mitochondrial D-loop RNA species which exhibits upregulated expression following
E L Duncan1, K Perrem, R R Reddel
1Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, Sydney, New South Wales, 2145, Australia.
Biochemical and Biophysical Research Communications
|October 12, 2000
Abstract:
We report the identification and characterization of a novel human mitochondrial RNA species approximately 0.47 kb long that is transcribed from the mtDNA L-strand and is derived from the D-loop. Its expression increases when human cells become immortal, a key event in tumorigenesis. The RNA is therefore designated IDL (Immortalization-associated D-Loop). Sequence and hybrid cell analyses suggest that the increased level of IDL RNA in immortal cells is due to a recessive change, possibly in the activity of a trans-acting factor that controls IDL RNA expression.