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Tryptophan 67 in the human VPAC(1) receptor: crucial role for VIP binding

P Nicole1, J J Maoret, A Couvineau

  • 1Unité de Neuroendocrinologie et Biologie Cellulaire Digestives, Institut National de la Santé et de la Recherche Médicale, Paris, 75018, France.

Biochemical and Biophysical Research Communications
|October 12, 2000
PubMed
Summary

Tryptophan 67 (W67) in the VPAC(1) receptor is crucial for VIP binding. Mutating W67 significantly impairs or abolishes VIP binding and adenylyl cyclase activation, highlighting its importance.

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