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Altered gene expression upon BCR cross-linking in Burkitt's lymphoma B cell line
Y Nakayama1, Y Iwamoto, S E Maher
1Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, 06520, USA. yasuhiro.nakayama@yale.edu
Abstract:
Burkitt's lymphoma cell line, BL2 was stimulated by surface BCR cross-linking and altered gene expression was analyzed by RDA methodology. Consistent with previous reports, we detected up-regulated MDC, IL6R and adhesion molecule LFA1. We also detected gene expression of SIRPalpha, anti-apoptotic A-20, signal regulatory SLP76 and BCAR3, DNA binding proteins EGR2 and DEC1 in addition to some new genes.
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