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Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Molluscicidal activity of 2-hydroxy-3-alkyl-1,4-naphthoquinones and derivatives
A F dos Santos1, P A Ferraz, A V Pinto
1Departamento de Química/CCEN, Universidade Federal de Alagoas, Maceió, Alagoas, 57072-970, Brazil.
Abstract:
In the search for new molluscicidal agents we tested the activity of lapachol and other 2-hydroxy-3-alkylnaphthoquinones possessing nitrogenated alkyl chains, against the snail Biomphalaria glabrata. Lapachol, isolapachol and nor-lapachol showed strong molluscicidal activity against the adult snail (LD(90)<10 ppm) and significant toxicity against snail egg masses (LD(90)<0.2 ppm). As lapachol is easily extracted, and the derivatives can be synthesised without any difficulty, large-scale synthesis and field tests can be conducted, with a view to large-scale molluscicidal programs.
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