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Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
07:41

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Published on: February 8, 2022

Acardiac anomaly spectrum.

C Mohanty1, O P Mishra, C P Singh

  • 1Department of Anatomy, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India.

Teratology
|October 12, 2000
PubMed
Summary
This summary is machine-generated.

A rare acardiac twin showed partial head and face development without upper extremities, challenging typical developmental patterns in twin reversed arterial perfusion (TRAP) sequence.

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Area of Science:

  • Developmental biology
  • Reproductive medicine
  • Congenital anomalies

Background:

  • Acardiac anomaly spectrum is a rare congenital malformation in monozygotic twin pregnancies.
  • Characterized by absence of the heart and variable developmental disruption.
  • No two cases present identically, highlighting unique pathological variations.

Observation:

  • This case report details findings from physical examination and autopsy.
  • The acardiac twin exhibited partial development of the head and face.
  • Complete absence of upper extremities was noted.

Findings:

  • The acardiac twin presented with significant cephalic development.
  • Notably, this occurred in the absence of upper extremity development.
  • This contrasts with the typical presentation where cephalic development correlates with upper extremity presence.

Implications:

  • The twin reversed arterial perfusion (TRAP) theory remains the leading explanation for acardia.
  • Findings suggest a complex interplay between perfusion and developmental patterning.
  • Further research is needed to understand the specific mechanisms driving acardiac anomalies with atypical limb development.