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Solid phase synthesis of tertiary amines on amide REM resins: Grignard and metal hydride compatible resins
M J Plater1, A M Murdoch, J R Morphy
1Department of Chemistry, University of Aberdeen, Scotland, UK.
Journal of Combinatorial Chemistry
|October 13, 2000
Abstract:
Four new amide REM resins (AM REM 2-5) are described, and their use is illustrated for the synthesis of tertiary amines 6-9 and 13-16. Amide REM resins 4 and 5, which have a phenyl ring attached to the amide nitrogen, are found to give superior product yields and purities, and the resins are stable to a wider range of reagents and conditions compared to REM resin 1.