Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Costimulation of T cells.

L Bugeon1, M J Dallman

  • 1Department of Biology, Imperial College of Science, Technology, and Medicine, London, United Kingdom.

American Journal of Respiratory and Critical Care Medicine
|October 13, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optical projection tomography implemented for accessibility and low cost (<i>OPTImAL</i>).

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2024
Same author

In vitro and in vivo properties of the bovine antimicrobial peptide, Bactenecin 5.

PloS one·2019
Same author

Notch signalling and voltage-gated Na+ channel activity in human prostate cancer cells: independent modulation of in vitro motility.

Prostate cancer and prostatic diseases·2006
Same author

Notch signalling in the regulation of peripheral immunity.

Immunological reviews·2001
Same author

Murine IL-10 gene transfer inhibits established collagen-induced arthritis and reduces adenovirus-mediated inflammatory responses in mouse liver.

Journal of immunology (Baltimore, Md. : 1950)·2001
Same author

In situ expression of soluble B7-1 in the context of oncolytic herpes simplex virus induces potent antitumor immunity.

Cancer research·2001

T cell activation relies on costimulation via B7 family molecules. Blocking CD28 and CTLA4 pathways with CTLA4-Ig shows therapeutic promise, with distinct roles for B7 family members in naive versus experienced T cells.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cellular Biology

Background:

  • Costimulation is essential for effective T cell activation.
  • The B7 gene family, including CD80, CD86, B7h/B7RP-1, and B7-H1, plays a key role in T cell costimulation.
  • CD80 and CD86 interact with CD28 and CTLA4 on T cells.

Purpose of the Study:

  • To investigate the roles of B7 family molecules in T cell activation.
  • To explore the therapeutic potential of blocking costimulatory pathways.

Main Methods:

  • Analysis of B7 gene family members and their interactions with T cell receptors.
  • Evaluation of CTLA4-Ig fusion protein as a therapeutic agent.

Main Results:

  • CD80 and CD86 primarily influence naive T cells.

Related Experiment Videos

  • B7h/B7RP-1 and B7-H1 appear to affect antigen-experienced lymphocytes.
  • CTLA4-Ig fusion protein demonstrates potential as a therapeutic agent by blocking these pathways.

    • Conclusions:

    • The B7 family of costimulatory molecules has distinct roles in T cell activation.
    • Targeting these pathways offers therapeutic opportunities in immunology.