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Related Experiment Videos

Metabolic age modelling: the lesson from centenarians.

G Paolisso1, M Barbieri, M Bonafè

  • 1II University of Naples, Naples, Italy, University of Bologna, Bologna, Italy. gpaoliss@tin.it

European Journal of Clinical Investigation
|October 13, 2000
PubMed
Summary

Healthy centenarians showcase successful age remodelling, demonstrating dynamic adaptations in metabolic and endocrine functions. This highlights a paradigm shift from simple decline to a complex, optimized aging process.

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Area of Science:

  • Gerontology
  • Immunology
  • Endocrinology
  • Metabolic Science

Background:

  • Aging theories suggest efficient anti-aging mechanisms in long-lived individuals.
  • The remodelling theory of aging posits that immunosenescence is an adaptive process involving both loss and gain.
  • The role of metabolic pathways and endocrine functions in age remodelling remains under-investigated.

Purpose of the Study:

  • To review age-related changes in metabolic pathways and endocrine functions.
  • To present healthy centenarians as exemplars of successful age remodelling.
  • To define the clinical profile of successful aging through the study of healthy centenarians.

Main Methods:

  • Review of existing literature on aging theories, immunosenescence, and remodelling.

Related Experiment Videos

  • Analysis of anthropometric, endocrine, and metabolic characteristics of healthy centenarians.
  • Comparative analysis between healthy centenarians and aged subjects.

    • Main Results:

    • Ageing involves progressive remodelling, not just decline.
    • Immunosenescence is a dynamic adaptation, not solely deterioration.
    • Healthy centenarians exhibit optimized metabolic and endocrine profiles, representing successful remodelling.

    Conclusions:

    • Healthy centenarians embody successful age remodelling, with optimized metabolic and endocrine functions.
    • The remodelling theory extends beyond the immune system to metabolic and endocrine functions.
    • Understanding these adaptations can inform strategies for healthy aging.