Related Experiment Videos
Preload dependence of color M-mode Doppler flow propagation velocity in controls and in patients with left
J E Møller1, S H Poulsen, E Søndergaard
1Department of Medicine, Svendborg Hospital, Denmark. jam@shf.fyns-amt.dk
Insights
Preload changes do not significantly affect flow propagation velocity (Vp) in healthy individuals or those with prior myocardial infarction (MI). Other echocardiographic measures, like E-wave velocity, are more sensitive to preload variations.
Area of Science:
- Cardiology
- Echocardiography
- Hemodynamics
Background:
- Left ventricular (LV) function is crucial in cardiovascular health.
- Assessing LV function often involves evaluating diastolic filling parameters.
- Flow propagation velocity (Vp) is an echocardiographic measure of diastolic function.
Purpose of the Study:
- To investigate the impact of preload alterations on color M-mode flow propagation velocity (Vp).
- To compare these effects in healthy volunteers and patients with depressed LV function (previous myocardial infarction).
Main Methods:
- Utilized color M-mode Doppler echocardiography.
- Performed assessments during Valsalva maneuver, passive leg lifting, and nitroglycerin administration.
- Studied 30 healthy volunteers and 30 patients with previous myocardial infarction.
Main Results:
- Mean Vp was significantly lower in myocardial infarction (MI) patients (46 cm/s) compared to controls (74 cm/s).
- Preload alterations caused minor, non-significant changes in Vp in both groups (controls P =.72, MI P =.31).
- Peak E-wave velocity, E/A ratio, and E-wave deceleration time showed significant changes with preload alterations in both groups.
Conclusions:
- Color M-mode flow propagation velocity (Vp) is not significantly influenced by preload changes.
- Other Doppler-derived diastolic parameters are more sensitive to preload variations than Vp.
- Findings are relevant for interpreting echocardiographic assessments of LV diastolic function in various clinical settings.
Abstract:
The purpose of this study was to assess the effects of preload alterations on color M-mode flow propagation velocity (Vp) in volunteers with normal left ventricular (LV) function and in patients with depressed LV function. Color M-mode Doppler echocardiography was performed during Valsalva maneuver, passive leg lifting, and after administration of nitroglycerin in 30 healthy volunteers and in 30 age- and sex-matched patients with previous myocardial infarction (MI). Mean Vp in controls was 74 +/- 15 cm/s at baseline and 46 +/- 15 cm/s in MI patients (P <.0005). In both groups, minor changes in Vp were seen during preload alterations; however, these were not significant (control P =.72, MI P =.31). In both groups, peak E-wave velocity (P <.0005), ratio of early-to-late peak velocities (P <.0005), and E-wave deceleration time (P <.0005) were found to change during preload alterations. In conclusion, we found that in controls and patients with previous MI, the color M-mode flow propagation velocity is not affected significantly by preload.