Related Experiment Videos
Human papillomavirus type 33 DNA in breast cancer in Chinese
Y Yu1, T Morimoto, M Sasa
1Department of Pathology, Shanghai First People's Hospital, China.
Background:
The association between human papillomavirus (HPV) and anogenital tumors, especially cervical cancer, is well documented. However, it remains unclear whether there is also a correlation between HPV infection and human breast cancer.
Methods:
We used PCR and Southern blot hybridization to analyze HPV-related DNA specimens from 32 cases of invasive ductal carcinoma operated upon in the Shanghai region of China.
Results:
DNA derived from HPV33 was detected in 14 cases (43.8%). No HPV16 or HPV18 DNA was detected in any of the cases in this study. This is the first report demonstrating a correlation between HPV33 infection and breast cancer.
Conclusions:
Our results suggest that HPV33 infection may be involved in the pathogenesis of breast cancer in Chinese.