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Updated: Jul 23, 2026
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The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
Published on: June 1, 2019
Multidisciplinary approach to selective sentinel lymph node mapping in breast cancer.
S P Leong1, E T Morita, P A Treseler
1Department of Surgery, University of California at San Francisco, School of Medicine, UCSF Comprehensive Cancer Center and Mount Zion Medical Center, 1600 Divisadero Street, Box 1674, San Francisco, CA 94115, USA.
Breast Cancer (Tokyo, Japan)
|October 13, 2000
Summary
Selective sentinel lymph node (SLN) dissection is a minimally invasive staging procedure for breast cancer. New intradermal injection techniques and multidisciplinary team approaches enhance SLN identification accuracy.
Area of Science:
- Oncology
- Surgical Oncology
- Nuclear Medicine
Background:
- Axillary lymph node dissection is crucial for breast cancer staging, with nodal involvement being a key prognostic indicator.
- Selective sentinel lymph node (SLN) dissection offers a less invasive alternative, sparing most patients extensive surgery.
- Current SLN dissection techniques involve blue dye and radiotracer methods.
Purpose of the Study:
- To review evolving techniques for selective SLN dissection.
- To propose a simplified intradermal injection approach for more reliable SLN identification.
- To emphasize the importance of a multidisciplinary approach for accurate SLN staging.
Main Methods:
- Review of existing literature on SLN dissection techniques.
- Discussion of peritumoral and intradermal injection methods.
- Emphasis on preoperative lymphoscintigraphy, intraoperative mapping, and pathological examination.
Main Results:
- Selective SLN dissection is a valuable staging tool, sparing 70-80% of patients from extensive axillary dissection.
- Intradermal injection may offer a quicker and more reliable method for identifying axillary SLNs.
- A multidisciplinary team approach is essential for maximizing the accuracy of SLN status determination.
Conclusions:
- Accurate breast cancer staging relies on precise SLN identification.
- A simplified intradermal injection technique holds promise for improved SLN detection.
- Optimal SLN identification necessitates close collaboration among nuclear medicine physicians, surgeons, and pathologists.
