Related Experiment Video
Updated: Aug 3, 2026

04:57
Establishing a Competing Risk Regression Nomogram Model for Survival Data
Published on: October 23, 2020
Cancer incidence and survival following bereavement
1Pan American Health Organization/World Health Organization, Washington, DC, USA. itzhak.levav@moh.health.gov.il
American Journal of Public Health
|October 13, 2000
Summary
Parental bereavement due to war or accidents increased cancer risk, particularly for lymphatic, hematopoietic, and melanoma types. Stress from losing a child accelerated death if cancer was diagnosed before the loss.
Area of Science:
- Epidemiology
- Oncology
- Psychosocial Medicine
Background:
- Parental bereavement is a significant stressor.
- The impact of profound grief on physical health, specifically cancer incidence and survival, requires further investigation.
Purpose of the Study:
- To investigate the association between parental bereavement and cancer incidence.
- To examine the effect of parental bereavement on cancer survival rates.
Main Methods:
- A cohort of 6,284 bereaved Israeli parents was followed for 20 years.
- Cancer incidence was compared between bereaved parents and non-bereaved individuals using logistic regression.
- Cancer survival in bereaved parents was compared with matched controls.
Main Results:
- Bereaved parents showed increased incidence of lymphatic and hematopoietic malignancies (OR=2.01 for accident victims, OR=1.47 for war victims).
- Increased melanoma incidence was observed in both groups (OR=4.62 and OR=1.71).
- Bereavement before cancer diagnosis did not affect survival, but bereavement after diagnosis increased mortality risk.
Conclusions:
- Parental bereavement is linked to increased incidence of specific cancers, suggesting stress-related mechanisms.
- The timing of bereavement relative to cancer diagnosis significantly impacts survival outcomes, with post-diagnosis loss accelerating demise.
Related Concept Videos
Cancer Prevention
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Kaplan-Meier Approach
The Kaplan-Meier estimator is a non-parametric method used to estimate the survival function from time-to-event data. In medical research, it is frequently employed to measure the proportion of patients surviving for a certain period after treatment. This estimator is fundamental in analyzing time-to-event data, making it indispensable in clinical trials, epidemiological studies, and reliability engineering. By estimating survival probabilities, researchers can evaluate treatment effectiveness,...
Comparing the Survival Analysis of Two or More Groups
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and Cox...
Cancer Survival Analysis
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
Psychoneuroimmunology: Diabetes and Cancer
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...

