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Updated: Aug 16, 2026

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
Novel ferrocenyl polyene derivatives and their binding to unmodified cyclodextrins
1Center for Supramolecular Science and Department of Chemistry, University of Miami, Coral Gables, Florida 33124-0431, and Chemistry Department, University of Florida, Gainesville, Florida 32611, USA.
Abstract:
Two new ferrocene derivatives, 7-ferrocenyl-2,4,6-heptatrienal (1) and 7-ferrocenyl-2,4,6-heptatrienol (2), were synthesized and characterized. These two compounds possess a rigid triene chain conjugated to one of the cyclopentadienyl rings of the ferrocene residue, and as a result, they exhibit very stiff structures. The electronic absorption and electrochemical properties of these compounds were utilized to investigate their host-guest binding interactions with the receptors alpha-cyclodextrin (alpha-CD) and beta-cyclodextrin (beta-CD) in aqueous solution. From electronic absorption measurements binding constants in the range 790-12900 M(-)(1) were obtained; beta-CD formed more stable complexes than alpha-CD with both guests. Electrochemical measurements suggest some degree of site selectivity in the complexation processes, with beta-CD binding preferentially to the ferrocene moiety while alpha-CD interacts with the unsaturated chain.
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