Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Large-scale shape changes in proteins and macromolecular complexes.

M E Wall1, S C Gallagher, J Trewhella

  • 1Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA. mewall@lanl.gov

Annual Review of Physical Chemistry
|October 14, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficient parallel linear scaling construction of the density matrix for Born-Oppenheimer molecular dynamics.

Journal of chemical theory and computation·2015
Same author

Effect of tannins on screening of plant extracts for enzyme inhibitory activity and techniques for their removal.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2012
Same author

The Third q-bio Conference on Cellular Information Processing.

IET systems biology·2010
Same author

Orienting rigid and flexible biological assemblies in ferrofluids for small-angle neutron scattering studies.

Biophysical journal·2009
Same author

Selected papers from the First q-bio Conference on Cellular Information Processing.

IET systems biology·2008
Same author

Determinants of bistability in induction of the Escherichia coli lac operon.

IET systems biology·2008
Same journal

Coadsorption of Atmospheric Surface-Active Organics at the Aqueous Interface: A Molecular Dynamics Study.

Annual review of physical chemistry·2026
Same journal

Control of Chemical Reactions in Radiofrequency Ion Traps.

Annual review of physical chemistry·2026
Same journal

Theories of Chiral-Induced Spin Selectivity: A Pedagogical Overview.

Annual review of physical chemistry·2026
Same journal

Quantum Computing Beyond Ground-State Electronic Structure: A Review of Progress Toward Quantum Chemistry Out of the Ground State.

Annual review of physical chemistry·2026
Same journal

First-Principles Simulations of Chemical Transformations in Nanoporous Materials and Industrial Catalysts.

Annual review of physical chemistry·2026
Same journal

Structure and Dynamics of Microhydrated Complexes Revealed with Rotational Spectroscopy.

Annual review of physical chemistry·2026
See all related articles

Proteins and RNA change shape to perform biological functions. Small-angle scattering is a powerful technique to study these large-scale molecular shape changes and their effects on behavior.

Area of Science:

  • Structural biology
  • Biophysics
  • Molecular dynamics

Background:

  • Proteins and RNA exhibit complex motions essential for biological functions.
  • These motions often involve significant conformational alterations, impacting molecular surface structure and shape.

Purpose of the Study:

  • To review the experimental characterization of large-scale shape changes in proteins and macromolecular complexes.
  • To explore the functional consequences of these conformational dynamics.

Main Methods:

  • Small-angle scattering (SAS) is highlighted as a key experimental technique.
  • SAS enables the determination of macromolecular shapes in solution.
  • SAS is crucial for elucidating the quaternary structure of macromolecular assemblies.

Related Experiment Videos

Main Results:

  • Review of significant findings obtained using small-angle scattering.
  • Demonstration of SAS's capability in characterizing large-scale molecular shape transitions.
  • Insights into how shape changes influence macromolecular behavior and function.

Conclusions:

  • Small-angle scattering is an increasingly powerful method for structural biology.
  • Understanding large-scale shape changes is vital for comprehending macromolecular function.
  • SAS provides critical data for determining the architecture of complex biological assemblies.