Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Breathing01:05

Breathing

50.7K
The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
50.7K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.5K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.5K
Asthma-I: Introduction01:29

Asthma-I: Introduction

3.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.6K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

3.5K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.5K
Asthma I: Introduction01:28

Asthma I: Introduction

360
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
360
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

73
Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
73

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Latrophilin receptors: novel bronchodilator targets in asthma.

Thoraxยท2016
Same author

Mechanical responsiveness of the endothelial cell of Schlemm's canal: scope, variability and its potential role in controlling aqueous humour outflow.

Journal of the Royal Society, Interfaceยท2011
Same author

Biomechanical effects of environmental and engineered particles on human airway smooth muscle cells.

Journal of the Royal Society, Interfaceยท2010
Same author

MEK modulates force-fluctuation-induced relengthening of canine tracheal smooth muscle.

The European respiratory journalยท2010
Same author

The temperature dependence of cell mechanics measured by atomic force microscopy.

Physical biologyยท2009
Same author

Universal behavior of the osmotically compressed cell and its analogy to the colloidal glass transition.

Proceedings of the National Academy of Sciences of the United States of Americaยท2009

Related Experiment Video

Updated: May 6, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 5, 2010

34.4K

Frozen objects: small airways, big breaths, and asthma.

J J Fredberg1

  • 1Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.

The Journal of Allergy and Clinical Immunology
|October 14, 2000
PubMed
Summary

Airway hyperresponsiveness in asthma may stem from altered myosin binding in airway smooth muscle. Lung development and allergic status appear to significantly influence this condition.

Area of Science:

  • Pulmonary Medicine
  • Cellular Biology
  • Immunology

Background:

  • Airway hyperresponsiveness is a key characteristic of asthma.
  • The underlying mechanisms of airway hyperresponsiveness are not fully understood.

Purpose of the Study:

  • To investigate the role of myosin binding in airway smooth muscle.
  • To explore how lung development and allergic status modulate airway hyperresponsiveness.

Main Methods:

  • The study introduces a new concept regarding myosin binding.
  • Analysis of mechanisms linking lung development and allergic status to airway hyperresponsiveness.

Main Results:

  • Perturbed myosin binding in airway smooth muscle is proposed as a novel explanation.

More Related Videos

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique
13:10

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique

Published on: May 15, 2013

59.1K
Rapid Viscoelastic Characterization of Airway Mucus Using a Benchtop Rheometer
08:47

Rapid Viscoelastic Characterization of Airway Mucus Using a Benchtop Rheometer

Published on: April 21, 2022

3.1K

Related Experiment Videos

Last Updated: May 6, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 5, 2010

34.4K
Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique
13:10

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique

Published on: May 15, 2013

59.1K
Rapid Viscoelastic Characterization of Airway Mucus Using a Benchtop Rheometer
08:47

Rapid Viscoelastic Characterization of Airway Mucus Using a Benchtop Rheometer

Published on: April 21, 2022

3.1K
  • Identified unanticipated mechanisms influencing airway hyperresponsiveness.

    • Conclusions:

    • Altered myosin binding may explain differences in airway narrowing between healthy and asthmatic lungs.
    • Lung development and allergic status are significant modulators of airway hyperresponsiveness.