Related Experiment Videos
Photosensitivity associated with treatment with triflusal
E Nagore1, A Pérez-Ferriols, J M Sánchez-Motilla
1Department of Dermatology, Hospital General Universitario, Valencia, Spain. eduyame@meditex.es
Summary
Triflusal, an antiplatelet drug, can cause systemic photosensitivity. A photopatch test confirmed triflusal and its metabolite triggered an immunological reaction in a patient.
Area of Science:
- Pharmacology
- Dermatology
- Immunology
Background:
- Triflusal is a fluorinated aspirin derivative used for thromboembolic disease prevention.
- It possesses antiplatelet properties, commonly prescribed in Spain.
Observation:
- A 91-year-old female experienced a systemic photosensitivity reaction after 15 days of triflusal treatment.
- Photobiological testing revealed abnormal responses to UVA/UVB radiation.
- Photopatch tests were positive for both triflusal and its primary metabolite.
Findings:
- The clinical presentation and photobiological results strongly suggest a causal link between triflusal and the photosensitivity reaction.
- The reaction is likely an immunological response, supported by previous case reports.
Implications:
- This case highlights a rare but significant adverse drug reaction to triflusal.
- Awareness of triflusal-induced photosensitivity is crucial for clinicians managing patients on this medication.