Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Heat shock factor 2 is activated during mouse heart development.

M Eriksson1, E Jokinen, L Sistonen

  • 1Haartman Institute, Department of Pathology, University of Helsinki, Finland.

The International Journal of Developmental Biology
|October 14, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of epicardial adipose tissue thickness and cardiac structure and function in early midlife - The cardiovascular risks in Young Finns Study.

European journal of preventive cardiology·2025
Same author

Coronary artery disease in patients with congenital heart defects.

Journal of internal medicine·2020
Same author

The implementation of a nationwide anomaly screening programme improves prenatal detection of major cardiac defects: an 11-year national population-based cohort study.

BJOG : an international journal of obstetrics and gynaecology·2018
Same author

Geographic origin as a determinant of left ventricular mass and diastolic function - the Cardiovascular Risk in Young Finns Study.

Scandinavian journal of public health·2018
Same author

Safety and effectiveness of female tubal sterilisation by hysteroscopy, laparoscopy, or laparotomy: a register based study.

BJOG : an international journal of obstetrics and gynaecology·2017
Same author

MEK and PI3K inhibition in solid tumors: rationale and evidence to date.

Therapeutic advances in medical oncology·2015

Heat shock transcription factor 2 (HSF2) is activated during mouse heart development, but not involved in heat shock gene regulation. HSF1 is abundant throughout heart formation.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Cardiovascular Research

Background:

  • Heat shock transcription factors (HSFs) regulate gene expression in response to cellular stress.
  • HSF1 is a classical stress-responsive factor, while HSF2 is implicated in embryogenesis.
  • The roles of HSF1 and HSF2 in heart development are not fully understood.

Purpose of the Study:

  • To investigate the expression and activation patterns of HSF1 and HSF2 during mouse heart formation.
  • To determine the relationship between HSF2 activation and heat shock gene expression during cardiac development.

Main Methods:

  • Analysis of HSF1 and HSF2 expression using molecular biology techniques.
  • Assessment of HSF2 DNA-binding activity during embryonic development.

Related Experiment Videos

  • Examination of heat shock gene expression in correlation with HSF2 activity.

    • Main Results:

    • HSF1 is abundantly expressed throughout mouse heart development.
    • HSF2 isoforms (HSF2-alpha, HSF2-beta, and a higher molecular weight isoform) are upregulated at embryonic day 11.5-12.5.
    • HSF2 DNA-binding activity is transiently induced during this period, while HSF1 mediates weak HSE-binding activity.
    • No correlation was observed between HSF2 expression/activation and heat shock gene expression.

    Conclusions:

    • HSF2 activation is specifically associated with key stages of mouse heart formation.
    • HSF2 does not appear to regulate inducible heat shock gene expression during cardiac development.
    • HSF1 plays a continuous role in regulating gene expression throughout heart development.