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Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

Published on: October 24, 2016

Multiple endocrine neoplasia in a dog.

M Kiupel¹, P B Mueller, J Ramos Vara

¹Animal Disease Diagnostic Laboratory, Purdue University, West Lafayette, IN 47907, USA.

Journal of Comparative Pathology

|October 18, 2000

Summary

A dog diagnosed with multiple endocrine neoplasms exhibited insulinoma, adrenocortical adenocarcinomas, and paraganglioma. These findings mirror human multiple endocrine neoplasia syndromes.

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Area of Science:

Veterinary Pathology
Comparative Pathology
Endocrinology

Background:

Multiple endocrine neoplasia (MEN) syndromes are rare inherited disorders in humans characterized by tumors in endocrine glands.
Understanding these syndromes in animals can provide insights into human disease mechanisms and potential therapeutic targets.

Observation:

A 12-year-old mixed-breed dog presented with anorexia, vomiting, diarrhea, weight loss, polyuria, polydipsia, regenerative anemia, and hypoglycemia.
Post-euthanasia examination revealed multiple endocrine neoplasms: an insulinoma, bilateral adrenocortical adenocarcinomas, and an aortic paraganglioma.

Findings:

Histopathological, immunohistochemical, and ultrastructural analyses confirmed the diagnoses of the endocrine tumors.
The combination of tumors observed in the dog closely resembles the human MEN syndrome.

Implications:

This case highlights the occurrence of multiple endocrine neoplasms in dogs, presenting a valuable animal model for studying human MEN.
Further research into canine endocrine neoplasia can advance comparative oncology and endocrine disease understanding.