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Lateralized P3 deficit in schizotypal personality disorder
M A Niznikiewicz1, M M Voglmaier, M E Shenton
1Harvard Medical School Department of Psychiatry, Brockton/West Roxbury VAMC, Brockton, Massachusetts 02301, USA.
Biological Psychiatry
|October 18, 2000
Summary
Individuals with schizotypal personality disorder (SPD) exhibit a reduced, left-lateralized P3 amplitude, similar to findings in schizophrenia. This study confirmed this electrophysiological deficit in SPD patients.
Area of Science:
- Neuroscience
- Psychiatry
- Cognitive Electrophysiology
Background:
- Schizophrenia is associated with reduced, left-lateralized P3 amplitude.
- Schizotypal personality disorder (SPD) shares similarities with schizophrenia.
- Previous research indicated a P3 amplitude deficit in SPD.
Purpose of the Study:
- To replicate the finding of a left-lateralized P3 amplitude deficit in SPD.
- To investigate electrophysiological differences between SPD and controls.
Main Methods:
- Event-related potentials (ERPs) were recorded.
- An auditory "oddball" P3 paradigm was used.
- 21 SPD subjects and 18 normal controls participated.
Main Results:
- SPD subjects showed lower P3 amplitude at T3 compared to T4.
- Control subjects did not exhibit this lateralized difference.
- This finding replicates previous observations.
Conclusions:
- The results support a left-lateralized P3 deficit in SPD.
- Electrophysiological findings in SPD mirror those in schizophrenia.
- This deficit may be a shared neurophysiological marker.