Lateralized P3 deficit in schizotypal personality disorder
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Updated: Oct 11, 2026

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
Published on: November 19, 2014
M A Niznikiewicz1, M M Voglmaier, M E Shenton
1Harvard Medical School Department of Psychiatry, Brockton/West Roxbury VAMC, Brockton, Massachusetts 02301, USA.
Background:
Reduced, left-lateralized P3 amplitude has been reported in several studies focusing on electrophysiologic function in schizophrenia. Also, several lines of evidence suggest a similarity between schizophrenia and schizotypal personality disorder (SPD). This study was undertaken to determine the replicability of our previous finding of a left-lateralized P3 amplitude deficit in SPD.
Methods:
We recorded event-related potentials in 21 SPD and 18 normal control subjects in an auditory "oddball" P3 paradigm.
Results:
In the SPD subjects, but not in the control subjects, there was lower P3 amplitude at T3 compared with T4.
Conclusions:
These results are similar to the ones in our previous work and further support the presence of a left-lateralized P3 deficit in SPD.
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